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This alteration represents a loss in BW of < 10% compared with control; this BW loss failed to reach toxicological significance.
Rather, such a genetic alteration represents a more general abnormality involved in the neoplastic transformation of a variety of cancers in different organs.
The same group also reported an 11p loss; however, our data show that this alteration represents a large 45 Mb segment at 11p15.5-p11.2 and an adjacent but distinct 2 Mb loss at 11p11.2.
To predict the size of alteration that could reliably be detected, given a fixed number of computationally sampled tags, we used Monte Carlo simulation to calculate a positive predictive value (PPV), which is the probability that a detected alteration represents a true alteration.
Similar(56)
This alteration represents an alternative mechanism to gene suppressor mutations and deletions and may affect indirectly the function of these genes in a similar fashion as mutations of TP53 [7].
Consequently, habitat alteration represents an important threat to a diversity of species that implement chemical, auditory, electrical, and visual signals in their communication systems (van der Sluijs et al. 2011; Rosenthal and Stuart-Fox 2012).
Given that the trial was six months in duration and we did not have a non-exercised control group, it is possible that this minor alteration represented a normal aging phenomenon.
However, none of these alterations represents a previously identified SNP based on a query of the dbSNP (build 125; ).
The study of these alterations represents a fascinating avenue to further elucidate the underlying mechanisms of cardiovascular disease.
FGFR gene alterations represent a target for treatment in clinical trials of urothelial carcinoma (UC).
All these findings strengthen the importance of molecular pathology where morphology and molecular alterations represent a powerful approach to diagnosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com