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In this context, the opportunity to investigate the environmental influences on epigenetic changes represents a new challenge to understand the role of epigenetics on CRC pathogenesis.
Finally, unravelling the epigenetic marks and mechanisms underlying these sex differences in physiological trajectories and in response to environmental changes represents a major health challenge.
Despite the great diversity among insects that belong to different orders, metamorphosis, a biological process by which the adult organism is formed through a series of gradual changes, represents a common feature.
The modification of proteins by post-translational changes represents a key regulatory mechanism of signal transduction that allows a rapid and dynamic cellular response to distinct environmental stimuli as well as to intracellular signals (Deribe et al, 2010).
Each of these changes represents a noncoding mutation from either a C to U or U to C in the third codon of the open reading frame; nucleotides at these positions may revert back to nucleotides observed in the more ancestral Old World strains.
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