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However, none of these alterations represents a previously identified SNP based on a query of the dbSNP (build 125; ).
The study of these alterations represents a fascinating avenue to further elucidate the underlying mechanisms of cardiovascular disease.
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FGFR gene alterations represent a target for treatment in clinical trials of urothelial carcinoma (UC).
All these findings strengthen the importance of molecular pathology where morphology and molecular alterations represent a powerful approach to diagnosis.
Since chromosomal CN alterations represent a key feature of cancer, well-performing GE/CN analysis methods are expected to have a good prioritization performance of known cancer genes.
However, in many cases, it was difficult to assess whether these alterations represented a correlative epiphenomenon or if they were causally linked to HCC pathogenesis.
This alteration represents a loss in BW of < 10% compared with control; this BW loss failed to reach toxicological significance.
Rather, such a genetic alteration represents a more general abnormality involved in the neoplastic transformation of a variety of cancers in different organs.
The same group also reported an 11p loss; however, our data show that this alteration represents a large 45 Mb segment at 11p15.5-p11.2 and an adjacent but distinct 2 Mb loss at 11p11.2.
To predict the size of alteration that could reliably be detected, given a fixed number of computationally sampled tags, we used Monte Carlo simulation to calculate a positive predictive value (PPV), which is the probability that a detected alteration represents a true alteration.
Subchondral bone alterations represent an essential component of osteoarthritis (OA).
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CEO of Professional Science Editing for Scientists @ prosciediting.com