Sentence examples for modification of drugs from inspiring English sources

Xenobiotic metabolism covers the biochemical modification of drugs and xenobiotics by living organisms.

Traditional methods to improve the blood compatibility include minimization of blood/material interactions, chemical modification of drugs on material surfaces and vascular endothelial cell seeding, which still do not meet the requirements of practical applications.

Specific mechanisms, such as target mutation or enzymatic modification of drugs, can only confer cross resistance within single antibiotic families.

This goal could be reached in at least two ways: (i) a chemical modification of drugs to produce less alcohol metabolites and (ii) a development of inhibitors of reductases which are responsible for transformation of ketone/aldehyde moiety to alcohol.

These results demonstrate that the modification of drugs via embedding in nanoparticles is a promising tool to facilitate drug delivery to the brain, which enables future development for the treatment of neurodegenerative disorders like AD. Alzheimer's disease (AD) is an age-related neurodegenerative disorder currently affecting more than 35 million people worldwide [ 1].

sEH has a broad substrate range, and because of its role in detoxification and biochemical modification of drugs, or their metabolites, the regioselectivity of the epoxide ring-opening reaction has important medical relevance, because of possible differences in activity between products.

Various strategies can influence drug design in the decision-making process in the structural modification of drug candidates to reduce metabolic instability.

The present paper deals with the modification of drug release from an HPMC‐based matrix tablet of a sparingly water‐soluble drug, prednisolone (PDL), using (SBE 7M‐β‐CD as a solubilizing agent.

Modification of drug delivery nanomaterials with affinity molecules that facilitate targeting, has rendered a new class of ligands for cell receptors, which often possess valency and dimensions different from natural counterparts.

This finding further supports the results obtained previously regarding colloid stabilization efficacy (Kasza, 2017) that amphiphilic hyperbranched polyglycerol is an ideal alternative to Pluronics in the functional surface modification of drug carrier NPs.

From these findings, particle-shape modification of drug crystals and dry particle coating with nanoparticle agglomerate using a mechanical powder processor is expected as an innovative technique for preparing controlled-release coated particles having high drug content and size smaller than 100 μm.