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Overall, the refined model was found to be superior to the initial model in predicting pregnancy-induced systemic exposure changes of drugs primarily metabolized by CYP3A.
FMI can be used to monitor changes of tumor before and after treatment of a certain drug, as well as changes of efficacy in response to dose changes of drugs.
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Genotypic monitoring of drug-resistance mutations (DRMs) in HIV-1 infected individuals is strongly recommended to guide selection of the initial antiretroviral therapy (ART) and changes of drug regimens.
Automated behavioral tests, lack sensitivity as some behavioral characteristics or subtle behavioral changes of drug effects or that are not considered in the overall analysis (Ohl et al., 2001) and observation-based analyses are not always performed.
In practice, because of the complexity and diversity of active components in herbal medicine, an analysis of condition changes of drug binding may promote the understanding of the molecular mechanisms involved and clinical relevance about them.
Instead, all six mutations present on exon 4 might together contribute to the alteration of the βI-tubulin's three dimensional structures, resulting in the changes of drug sensitivity in KB-L30 cells.
They also complained about frequent changes of drug regimes for people living with HIV/AIDS.
Therefore, based on the patients' baseline condition, substantial changes of drug treatment were reported.
This is in addition to variances seen secondary to age-related pharmacodynamic and pharma-cokinetic changes of drug metabolism.
Our sampling methods (RDS) did not change over the three surveys and no substantial changes of drug availability have occurred over the period under observation [ 25, 42].
There're several advantages of using Taiwan's NHI database [ 14] to quantify the changes of drug expenditure, utilization and market structure after policy interventions.
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