Sentence examples for modifications of drugs from inspiring English sources

The passage of drugs through the BBB may be improved through biological modifications of drugs involving the coupling of the drug to a receptor-targeted delivery vector such as a genetically engineered peptidomimetic monoclonal antibody[21 24].

The mean follow-up period was 89 days (62 115 days), and during the follow-up there were no significant modifications of drugs among patients.

To avoid such adverse side effects, studies have looked at both modifications of drug action and alternative methods of drug delivery.

The major approaches used are chemical modifications of drug molecules and/or new drug delivery systems, which offer better targeting to the upper skin layer, faster onset, and lower concentrations.

Xenobiotic metabolism covers the biochemical modification of drugs and xenobiotics by living organisms.

Traditional methods to improve the blood compatibility include minimization of blood/material interactions, chemical modification of drugs on material surfaces and vascular endothelial cell seeding, which still do not meet the requirements of practical applications.

Specific mechanisms, such as target mutation or enzymatic modification of drugs, can only confer cross resistance within single antibiotic families.

This goal could be reached in at least two ways: (i) a chemical modification of drugs to produce less alcohol metabolites and (ii) a development of inhibitors of reductases which are responsible for transformation of ketone/aldehyde moiety to alcohol.

These results demonstrate that the modification of drugs via embedding in nanoparticles is a promising tool to facilitate drug delivery to the brain, which enables future development for the treatment of neurodegenerative disorders like AD. Alzheimer's disease (AD) is an age-related neurodegenerative disorder currently affecting more than 35 million people worldwide [ 1].

sEH has a broad substrate range, and because of its role in detoxification and biochemical modification of drugs, or their metabolites, the regioselectivity of the epoxide ring-opening reaction has important medical relevance, because of possible differences in activity between products.

But to delay that process for as long as possible, drug companies often make additional patent claims, sometimes on modifications of their drugs or of the way that the drug is delivered.