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Biomimetic strategies are designed for modification of therapeutics emulating enzymatic strategies found in Nature.
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The SBA-15 platform allows for the delivery of protein therapeutics without direct modification of the desired therapeutic.
Furthermore, the key interaction of boronic acids with diols allows utilisation in various areas ranging from biological labelling, protein manipulation and modification, separation and the development of therapeutics.
Here, we show that the modification of protein and peptide therapeutics with tannic acid a flavonoid found in plants that adheres to extracellular matrices, elastins and collagens improves their ability to specifically target heart tissue.
Changes in patient severity or modification of care practices and therapeutics along time could be other explanative factors.
Translational efforts to develop other RNA therapeutics have shown that judicious chemical modification of RNAs can improve therapeutic efficacy by reducing susceptibility to nuclease degradation.
Such seemingly inherent targeting, in addition to further modification of the dendrimer to incorporate therapeutics, makes the dendrimer class of nanomaterials clinically-relevant.
A better understanding of the covalent modifications of oligomers could have a huge impact on the development of therapeutics for neurodegenerative diseases.
Rational modification of epitope GlcNAc puckering kinetics can be expected to modulate protein recognition and thereby facilitate development of therapeutics (Jefferis 2009).
Genetic modification has been used but is limited to products that can be manufactured by cells and release kinetics of therapeutics cannot easily be controlled.
In particular, the preparation, characterization, and surface modification of nanoparticles, and their application in cancer therapeutics are discussed.
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