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If the patient had no twitch, no modification of dosage was performed and TOF was monitored every 4 h.
This will be particularly important for longitudinal research, wherein there is typically some degree of "trial and error" modification of dosage and injection site during ongoing re-injections.
However, modification of dosage or time accounted for 9 and 41% of cases (P<0.001), and interruption due to toxicity were 9 and 13% (P=NS), respectively.
The major concern for retreatment with bortezomib is drug resistance and toxicity, and this could be relatively controllable with vigorous monitoring of toxicities and modification of dosage.
Time-sensitive actions to optimally manage DILI include discontinuation of the study drug in a timely manner, avoiding re-challenge, modification of dosage, performance of time-sensitive diagnostic tests and institution of therapeutic interventions.
This may result from ongoing modification of dosage and injection site (Blitzer et al 1998) or from a long-term improving trend that has been noted in some longitudinal BT studies, the mechanism of which remains unclear (Mehta et al 2001; Salvatore et al 2007).
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Further modification of the dosage of this regimen or addition of prophylactic G-CSF should be considered in the management of these patients.
CNVs can influence phenotypic variation and adaptation by modification of gene dosage, gene expression, or disruption of genes that span boundaries of structural rearrangements.
Developmental changes are rapid during the first weeks and months of life, thus requiring continual modification of drug dosage regimens designed for treating pediatric patients.
Hypoglycemia, the major complication of insulin therapy, is avoidable in the majority of cases with appropriate use of either intravenous or basal-bolus insulin regimens with regular monitoring of bedside BG levels and modification of insulin dosage in response to changes in clinical and nutritional status (1, 7, 8).
Modification of AED therapy (addition or subtraction of therapies, and/or adjustment of dosage) was unrestricted throughout the study.
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