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After the first year or two, intensive management relied more on appropriate adjustments of dosage than on adding new medications.
Thereafter, the emphasis was on individualized adjustments of dosage and instruction of participants on the medication and lifestyle regimen assigned, especially in the case of insulin therapy.
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The individual adjustments of dosages were used in greater extent since the GFR value was given automatically and together with advice on dosages.
Fourth, for diabetes mellitus, our measure of physician response was not applicable to patients with insulin treatment as data on day-to-day adjustments of dosages were not reliably recorded.
AKI necessitates adjustment of dosage of renally eliminated drugs and avoidance of nephrotoxic drugs.
Modification of AED therapy (addition or subtraction of therapies, and/or adjustment of dosage) was unrestricted throughout the study.
Adjustment of dosage of insulin glargine was permitted throughout randomized treatment targeting fasting SMPG 4.4 5.6 mmol/L (80 100 mg/dL).
The ideal level of sedation varies for different situations, and the adjustment of dosage should always be considered when a patient's needs change [ 4, 18].
In contrast, the weight gain of WA-treated mice indicated the potential clinical benefit of WA in reduced adverse toxicity and the feasibility for upward adjustment of dosage for improved treatment outcomes compared with cisplatin.
To specify the change in antidepressant use, those reporting had to select one of the following categories: discontinuation, switching to other treatment, adjustment of dosage or administration, any other action taken or no action taken.
4 However, patients show considerable variability in their response to warfarin, which, coupled with a narrow therapeutic range, necessitates frequent monitoring and adjustment of dosage to ensure optimal anticoagulation.
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