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To be included, patients had to be aged 18 years or over, presenting as in- or out-patients for the treatment of acute or mixed mania, and initiating or changing oral medication for mania (except for a change of dosage).
According to Jeff Kimmell, vice president for pharmacy, traditional drugstores can offer those services because they can resell the drugs if the customer does not pick them up, but mail-order prescription drugs cannot be returned to the company for any reason -- be it a change of address or change of dosage.
Patients required a stable medication with no change of dosage within the last six months.
The change of dosage between the assessments was also calculated using the percentage of maximum dose.
A change of dosage within the same drug, however, is tolerated.
Voriconazole concentrations were determined on day 3 after the start of therapy and always 3 days after change of dosage.
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For the intensive treatment group, decisions on addition or discontinuation of drugs or changes of dosage were to be made at each visit.
Compared to PD-NC, levodopa equivalent daily dose intake was significantly higher in PD-MCI (P < 0.001) at baseline but there were no significant differences in levodopa equivalent daily dose intake at follow-up and changes of dosage over 18 months.
Non-reciprocal translocations usually cause the change of gene dosage.
In addition, a switch to another antipsychotic drug or change of its dosage may be sometimes required.
All participants used short-acting betamimetics on demand without change of the dosage or frequency in the course of the study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com