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Exact(5)
Both indices demonstrated heterogeneity (non-uniformity) across gestational age strata, indicating the presence of effect modification by gestational age.
To assess effect modification by gestational age for the association of early infection with asthma, interaction testing using the entire (non-stratified) study population was undertaken.
Caution needs to be used in interpreting these results because our analyses also confirmed the presence of effect modification by gestational age for both indices, with the association between inadequate/no care and LBW becoming stronger as gestational age increased.
However, our findings still showed some degree of effect modification by gestational age when studying the association between inadequate/no PNC and SGA, so the results should be interpreted with caution.
When stratified by gestational age (and with additional adjustment for birth weight), there is statistically significant effect modification by gestational age, with the highest magnitude asthma risk among those born with a gestational age of less than 28 weeks, producing an adjusted HR of 2.22 (1.59 to 3.09).
Similar(55)
Routinely collected newborn infant screening metabolic analytes vary by gestational age and may be useful to estimate gestational age.
Are the associations mediated by gestational age?
These ratios change little by gestational duration within this range.
Interaction testing among the entire study population confirms statistically significant effect modification by the most premature gestational age group, at less than 28 weeks compared with the infants who were born at term.
We evaluated effect modification by established risk factors for gestational diabetes including age (<35 v ≥35), BMI before pregnancy (<25 v ≥25), family history of diabetes (yes, no), and race (white v non-white) by conducting stratified analyses.
The associations were little affected by gestational age, parity adjustment or exclusion of mothers with gestational diabetes.
Related(13)
adjustment by gestational
variation by gestational
modified by gestational
modification by maternal
modification by proteolytic
modification by molecular
modification by dietary
modification by folic
modification by iAs
modification by noch
modification by functionalized
modification by patient
modification by bifunctional
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