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With the large prevalence of chronic low back pain even modest predictive ability could make a substantial contribution to health systems worldwide.
Furthermore, analysis of these biomarkers on an individual patient basis using ROC analysis showed that they have only modest predictive ability for ACR50 outcome to adalimumab or tocilizumab at 24 weeks.
Despite the modest predictive ability, some argue that genetic risk models can still be useful in health care and disease prevention to identify individuals at very high risk [ 10].
Although the results of Dennis and colleagues [ 1] are scientifically important and demonstrate the importance of gene expression profiling in the search for predictive biomarkers, the individual patient-based ROC analyses show only modest predictive ability and therefore weak clinical utility.
sICAM1 and CXCL13 showed only modest predictive ability for adalimumab or tocilizumab on an individual patient basis based upon their respective AUCs (0.57 and 0.6 respectively, Additional file 12: Figure S9A, D), whereas assessment of the two biomarkers in combination showed slight increases in the respective AUCs (Additional file 12: Figure S9C, D, E, F).
Similar(55)
In contrast, prediction models based on measurements made during fasting states do not have the ability to assess β-cell function and, therefore, have modest predictive power for future diabetes risk compared with the 1-h plasma glucose concentration after a glucose challenge.
These are factors that have some modest predictive power.
Yet there's good reason to believe that we are on the road to more active development of behavioral genetics with at least modest predictive power.
These results show that the attributes we chose each have at least modest predictive power.
Further explanations are offered for the modest predictive power for intentions and behaviour.
We see that these long-range predictors carry a modest degree of predictive ability, again with the caveat that this sample covers a series of turbulent periods.
Related(17)
low predictive ability
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modest predictive utility
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modest athletic ability
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moderate predictive ability
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