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See Additional file 2 for full derivation of all models and P values.
Heterogeneity of associations of APOE genotypes with each outcome were assessed by analysis of covariance models and p values reported.
We defined statistical significance as two-tailed p < 0.05 for the single-metal models and p < 0.10 for the multiple-metal models.
Models were refined by a process of backward elimination of variables not contributing significantly to the fit using the change in log likelihood of successive models and p < 0.05 as the criterion for statistical significance.
Among the 28 polymorphisms tested, two intronic polymorphisms (+ 20511C> T and + 22693T> C) were associated with asthma risk (Fig. 1a; Table 2; p = 0.001 in co-dominant and dominant models and p = 0.0006 in a recessive model).
All 3 models showed that mortality risk was approximately 50% higher in patients with chronic hepatitis C than in patients with prior hepatitis C, but the increase was not statistically significant: 95% CIs were 1.0 1.5 in all 3 adjusted models and P values were.07.07
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We then go on to describe the basis of the assessments—"gold standard" test sets, scoring metrics, null models and p-values.
Statistical analyses for cord plasma parameters were performed by multiple linear regression models and p-values were adjusted for infant sex and pregnancy duration.
The proportion of the variance (R) explained was obtained from the regression models and p-values were used to describe statistical stability.
Table 2 presents combined effect estimates for crude (adjusted for sex and municipality) and adjusted (adjusted for all potential confounders) models and p-values for heterogeneity.
Dose response associations (p-trend) were examined for ordinal variables which could be treated as continuous assuming a linear trend in the models and p-nominal values were estimated for all variables.
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