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Reduction of mitochondrial genome content was associated with the aggressive phenotype of prostate cancer in vitro cell line model and tissue specimens in vivo.

Animal model and tissue culture studies have provided evidence for crystal retention within the kidneys via attachment to renal epithelial cells.

The relationship between the distribution volumes and clearances of the empirical model and tissue capacities and blood flow of the physiological model are complex, however.

It was ascertained in a preliminary study that investigated baseline variation in this model and tissue type, that n=10 was a sufficient sample (see Gene Expression Omnibus (GEO) accession number GSE13802 for the complete dataset of this pilot study).

Our findings of increased proteostatic mechanisms in Snell mice are in accordance with long-lived CR, Rap, and CL mouse models of the same age (model and tissue comparisons are summarized in Table S1) (Miller et al., 2012a, b; Drake et al., 2013, 2014).

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We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration.

Regenerative medicine, including preclinical studies in large animal models and tissue engineering approaches as well as innovative assays for drug discovery, will require the constant supply of hPSC-derived cardiomyocytes and other functional progenies.

We show that especially for inducible promoters, crosstalk effects can cause a substantial distortion in the expression of proximal genes, challenging established strategies in generating transgenic animal models and tissue culture systems.

Thus, hESC and hiPSC differentiation offers a unique opportunity for therapy development, drug screening, disease modeling, and tissue replacement.

We analyzed the function of Alx4 during GT formation with a series of genetically modified mouse models and tissue labeling experiments.

There is an accumulating body of data coming from human biopsies, human TTR transgenic mouse models and tissue culture systems, indicating that in the TTR amyloidoses, tissue dysfunction precedes TTR fibril deposition [ 8, 11– 13].

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