Clinical observations and studies in animal models and tissue cultures indicate that Stx2a, the SPATEs Pic and SigA, as well as the pAA-encoded virulence factors, in particular AAF/I, contributed to the high pathogenicity of the outbreak strain5,6,7,8.
We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration.
We show that especially for inducible promoters, crosstalk effects can cause a substantial distortion in the expression of proximal genes, challenging established strategies in generating transgenic animal models and tissue culture systems.
Regenerative medicine, including preclinical studies in large animal models and tissue engineering approaches as well as innovative assays for drug discovery, will require the constant supply of hPSC-derived cardiomyocytes and other functional progenies.
We analyzed the function of Alx4 during GT formation with a series of genetically modified mouse models and tissue labeling experiments.
There is an accumulating body of data coming from human biopsies, human TTR transgenic mouse models and tissue culture systems, indicating that in the TTR amyloidoses, tissue dysfunction precedes TTR fibril deposition [ 8, 11– 13].
