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This is of obvious relevance because neuronal excitability depends on energy metabolism and because convergent data from various laboratories have shown that brain oxidative metabolism, mitochondrial functioning, and energetic production are significantly reduced in the brain of migraineurs between attacks [44 46].

In summary, carnosine has a strong effect in restoring mitochondrial functioning and in counteracting amyloid pathology but these activities do not translate in a robust effect on cognition.

There is an increasing amount of evidence that KD can improve mitochondrial functioning and stimulate mitochondriogenesis [ 57– 60].

In Arabidopsis thaliana, mutated mTERF15 led to defective mitochondrial functioning and significantly disturbed normal plant vegetative to reproductive growth [ 74].

NAA is widely interpreted as a neuronal marker and implicated in several neuronal processes, including lipid and protein synthesis, mitochondrial functioning, and osmoregulation.

The NAA functions in the brain as an acetyl donor for acetyl coenzyme A and has been implicated in several neuronal processes, including lipid and protein synthesis, mitochondrial functioning, and osmoregulation [ 25, 26].

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Dr. Ronald M. Evans, an expert on the hormonal control of metabolism at the Salk Institute, said the report by Dr. Auwerx's team had "shown very convincingly that resveratrol improves mitochondrial function" and fends off metabolic disease.

Membrane architecture is crucially important for mitochondrial function and integrity.

It is well established that mitochondrial function and activity are primary determinants of longevity.

This was accompanied by impaired mitochondrial function and an increased proportion of apoptotic cells [97].

Decreased mitochondrial function and altered mitochondrial biogenesis are implicated in the pathogenesis of sepsis-induced muscle dysfunction [3].

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