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Desai, S. P., Bhatia, S. N., Toner, M. & Irimia, D. Mitochondrial localization and the persistent migration of epithelial cancer cells.
An unknown subset of these events are associated with seemingly disparate gains of function, including catalysis of self-assembly, membrane penetration, loss of membrane integrity, mitochondrial localization, and finally, cytotoxicity, a central component of diabetic pathology.
Open image in new window Figure 3 Impairment of Trak1 mitochondrial localization and function by hypertonia-linked mutation.
We found that hypertonia-associated mutation impairs Trak1 mitochondrial localization and its ability to facilitate mitochondrial tethering and fusion.
The results of cellular uptake, mitochondrial localization, and cytotoxicity showed the Cur/TPP-oHA-S-S-Cur micelles had CD44 receptor-targeting ability and mitochondrial targeting ability.
This dynamic change in B cell survival mechanisms is unique to virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.
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This method can be expanded to confirm sub-mitochondrial localization and membrane topologies of previously identified mitochondrial proteins.
We next determined the sub-mitochondrial localization and membrane orientation of PTPIP51 using three different assays.
Although PTPIP51 is a mitochondrial protein (29), its precise sub-mitochondrial localization and membrane orientation are not known.
p32 [also known as HABP1 (hyaluronan-binding protein 1), gC1qR (receptor for globular head domains complement 1q) or C1qbp (complement 1q-binding protein)] has been shown previously to have both mitochondrial and non-mitochondrial localization and functions.
Thus, reengineered guide-RNA would require the development of mitochondrial localization- and single-base-pair-distinguishing capabilities.
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mitochondrial function and
mitochondrial fusion and
mitochondrial activity and
mitochondrial disease and
mitochondrial genome and
mitochondrial depolarization and
mitochondrial morphology and
mitochondrial health and
mitochondrial quality and
mitochondrial fragmentation and
mitochondrial status and
mitochondrial phosphorylation and
mitochondrial maintenance and
mitochondrial plastid and
mitochondrial abundance and
mitochondrial mt and
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