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Retaining the otherwise periplasmic GGT in the cytoplasm was critical for the functionality of the system, as was fine-tuning its expression in order to minimize toxic effects associated to cytoplasmic GGT expression.
It has been suggested that lower amounts of polyplexes minimize toxic effects of PEI and also minimize cell aggregation, leading to higher productivity after transient transfection [ 19].
Further, to lower down the risk of nanoparticle generated cytotoxicity and invasiveness, biodegradable biomaterials should be used to minimize toxic effects in the brain.
In contrast to our model, standardized intensive care management, including fluid resuscitation, catecholamines, and mechanical ventilation to minimize toxic effects of acetaminophen, has never been established.
Our current study provides a new strategy of utilization of natural existing bioactive peptides, such as ACBP-L used in this study, to potentiate chemotherapeutic effects and minimize toxic effects.
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Chronotherapy and chronopharmacology are currently utilized in cancer treatments, aiming to minimize toxic side effects while maintaining effective treatment.
Understanding the molecular events that contribute to survival of and drug-induced apoptosis in hematopoietic stem and progenitor cells (HSC/P) can have impact on more rational approaches to blood cancer therapeutic design, as well as on strategies to minimize toxic side effects of chemotherapeutic drugs.
Such regimen would minimize toxic side effects by reducing drug exposure, at the same time allowing sustained upregulation of frataxin protein.
The combination of the two modalities may minimize toxic side effects [ 70, 74].
These characteristics potentially minimize toxic side effects exerted by pharmacological inhibition of the cellular targets.
"We wanted a drug that inhibits a protein that is only expressed in cancer cells, not in normal cells, in part because we believed this would minimize toxic side effects".
Related(18)
minimize harmful effects
minimize deleterious effects
minimising toxic effects
minimizes toxic effects
minimized toxic effects
minimize adverse effects
minimize epigenetic effects
minimize toxic compounds
minimize such effects
minimize toxic effluents
minimize diurnal effects
minimize negative effects
minimize bulk effects
minimize electrostatic effects
minimize toxic side-effects
minimize toxic emissions
minimize detrimental effects
minimize experimental effects
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