Retaining the otherwise periplasmic GGT in the cytoplasm was critical for the functionality of the system, as was fine-tuning its expression in order to minimize toxic effects associated to cytoplasmic GGT expression.
It has been suggested that lower amounts of polyplexes minimize toxic effects of PEI and also minimize cell aggregation, leading to higher productivity after transient transfection [ 19].
Further, to lower down the risk of nanoparticle generated cytotoxicity and invasiveness, biodegradable biomaterials should be used to minimize toxic effects in the brain.
In contrast to our model, standardized intensive care management, including fluid resuscitation, catecholamines, and mechanical ventilation to minimize toxic effects of acetaminophen, has never been established.
Our current study provides a new strategy of utilization of natural existing bioactive peptides, such as ACBP-L used in this study, to potentiate chemotherapeutic effects and minimize toxic effects.
Perhaps consistent with this idea, Smith et al. (2006) were able to show that introducing a K1347A mutation, which can bind neither GDP nor GTP and has lower kinase activity, minimizes the toxic effects of G2019S LRRK2.
It is well known that traditional CPAs must be washed away and replaced with the fresh medium right after recovery to minimize their toxic effects.
His focus is to develop safer drugs that selectively target the unique biology of the cancer cell, all in an effort to minimize the toxic effects of existing chemotherapy treatments.
This study was designed to investigate the reproductive toxicity of TDN in male albino rats and the ameliorative role of Tiron to minimize such toxic effects.
To minimize the toxic effects of receptor overexpression, stable hOR17-4-inducible HEK293S cell lines were created using the Invitrogen T-REx tetracycline regulation system (Materials and Methods).
