Sentence examples for minimising toxic effects from inspiring English sources

BLT is designed to specifically target surface receptors that are overexpressed on cancer cells, thereby minimising toxic effects to normal tissue.

The challenge for the next decade is to optimise these treatments to improve antitumour effects and to minimise toxic effects in normal tissues.

Whilst therapeutic drug monitoring (TDM) has traditionally been used to minimise toxic effects, the study results support emerging data that TDM should also be used to optimise dosing in critically ill patients.

They propose sealing the nanoparticles within a thin shell of silica to minimise any toxic effects.

Nick Coleman, professor of molecular pathology at Cambridge University said: "We need new ways of treating patients with malignant germ cell tumours to minimise the toxic effects of chemotherapy and to improve survival rates when tumours are resistant to treatment.

A further advantage in the use of continuous low-dose chemotherapy is that it minimises the toxic effects of drugs, allowing more combinations of potentially synergistic selective inhibitors of angiogenesis.

We chose a relatively mild treatment, slightly under the IC50, in order to minimise general toxic effects in cell membranes and widespread DNA damage.

We analysed this effect in vivo at the transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal (IC40) concentrations of the drug to minimise general toxic effects.

siRNA treatment was performed for 48 h before protein or mRNA expression analysis in an effort to minimise the potentially toxic effects caused by the loss of PLK1.

To identify conditions that maximise transfection efficiency and minimise lipid-mediated toxic effects, multiple transfection conditions for each cell line were tested.

Because of their toxic effects, the quantity of contaminants is often minimised in raw material (9, 10).