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Next, we sought to determine by which mechanism TAM might induce cellular stress.
One possible explanation for the effect of Nutlin-3 that we have observed is that, upregulation of p53 might induce cellular senescence.
Then, the cold signal transduction might induce cellular metabolism changes, such as the calcium signaling cascade, hormone signal transduction, and ROS signaling.
These results indicate that hypoxia during early embryonic craniofacial development might induce cellular oxidative stress, leading to apoptosis of the neural crest progenitor cells that are crucial to normal craniofacial morphogenesis.
Male workers exposed before the age of 20 fathered significantly more girls, leading the researchers to propose that dioxin might induce cellular changes in the leydig and sertoli cells that could still affect Y-bearing sperm years later.
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Treatment of MCF-7 breast cancer cells with DZNep led to the derepression of a defined set of Polycomb targets, which again suggested that the compound might also induce cellular differentiation [14].
8, 9 These findings suggest that TGF-β1/H2O2/HOCl might not induce cellular senescence, as cellular senescence could reduce the clonogenicity and tumorigenicity of tumor cells.
They also suggest that the differential cellular signal responses to disparate microenvironments within different purification methods used for preparation might induce distinct cellular behaviors after OEC transplantation.
The presence of a cariogenic species, like S. mutans, and/or biomaterials, like HEMA, alone and in combination with each other, might induce a cellular response of the oral tissues, in terms of gene and protein expression [ 26, 27].
Most dengue vaccine candidates and diagnostic methods available nowadays, make use of some part of the E glycoprotein and these peptides might be able to induce cellular and humoral responses.
Furthermore, such cell envelope dynamics might account for the adaptive mechanisms toward β-myrcene hydrophobicity, which might affect overall membrane integrity and induce cellular stress (Sikkema et al. 1995; Turina et al. 2006; Cox and Markham 2007).
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