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Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.
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Although both the RasGEFs and RasGAPs proteins are needed to complete a full GTPase cycle and to allow for a switch between an inactive and active state of Ras, the activation state of these Ras proteins, but not the level of expression, might determine the cellular effects.
Gene regulatory networks determine cellular identity.
To determine cellular localization, pSORT was used (http://wolfpsort.seq.cbrc.jp/).seq.cbrc.jp/
These factors determine cellular response to signals.
For logistic reasons, we did not determine cellular composition.
In the current paper, we propose a new bone metabolic unit which highlights the role of MSCs, and upon which we identified cAMP/PKA signaling, one of the many signaling pathways that regulate bone homeostasis, which might determine the constitution of the cellular components via directing adipogenesis, osteogenesis and osteoclastogenesis by controlling the release of leptin from MSCs (Fig. 6).
Thus, the cellular cholesterol status might determine if HDL is cholesterol loaded or depleted during retro-endocytosis.
This model implies local differences in lipophilicity and membrane fluidity, which in turn might determine the site and efficiency of cellular drug entry.
Zalypsis showed a different sensitivity profile from trabectedin in the cell line panel studied, indicating that alternative activities in cellular pathways or specific trends of intracellular metabolism might determine different activities.
The net effect might determine quality of the cytokine and chemokine response that directs strength and timing of subsequent cellular-mediated innate immune mechanisms (Nian et al, 2004).
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