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Previously we demonstrated the utility of a modified histone peptide microarray to characterize methyl-lysine effector functions for the PHD fingers present within the yeast proteome [13].
Finally, Blanchard et al have used a human microarray to characterize the impact of PrV infection in human embryonic kidney cells (HEK-293) [ 14].
Chen et al. elected to use an E. coli proteome microarray to characterize the differential immune response (serum anti- E. coli antibodies) in patients with CD and UC compared to healthy controls (HC).
These results highlight the benefits of using the PathogenID v2.0 resequencing microarray to characterize geographical variants in the follow-up of haemorrhagic fever epidemics; to manage patients and protect communities; and in cases of bioterrorism.
This study demonstrates the strength of using a forward approach (microarray) to characterize a developmental phenomenon (wound healing) at a phylogenetically important crossroad of animal evolution (cnidarian-bilaterian ancestor).
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Study Design: The current literature relating to microarray technology and methodology is reviewed, specifically the use of DNA microarrays to characterize gene expression.
Microarrays to characterize single nucleotide polymorphisms (SNPs) provide a cost-effective and rapid method (under 24 h) to genotype microbes as an alternative to sequencing.
We utilized Affymetrix U95Av2 microarrays to characterize the molecular alterations that underlie omental metastasis from 47 epithelial ovarian cancer samples collected from multiple sites in 20 patients undergoing primary surgical cytoreduction for advanced-stage (IIIC/IV) serous ovarian cancer.
There have been a few genome-wide screens using DNA microarrays to characterize the eukaryotic transcriptional response to HS in C. elegans [23], human cell lines [24], [25], Drosophila embryos [26], and Drosophila adults [27].
To further advance the understanding of genes underlying the development of AE, and to test the impact allergens may have on the global expression pattern in AE skin, we used cDNA microarrays to characterize the global gene-signature in lesional skin and patch-tested skin from eczema patients and corresponding skin from healthy individuals.
In contrast to previous work, this study utilized mRNA sequencing, rather than microarrays, to characterize the transcriptome.
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