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Microarray studies conducted to discover molecular pathways linked with tumour progression and papers comparing metastases to initial tumours have already been performed [37] [41].
However, some apparent discrepancies were found between the data presented here for Aedes and the microarray studies conducted in Anopheles, which showed reduced expression of genes related to oxidative phosphorylation and TCA cycle after blood feeding [40], [41].
The stable induction of CKX5 by cytokinin was confirmed in 9 of 13 microarray studies conducted by different labs [ 49].
However, prioritizing the long lists of genes produced by comparative microarray studies conducted in either species has proven exceedingly difficult.
Several microarray studies conducted in genetically modified mice reported very distinct global gene expression profiles between animals exhibiting high or low glycogen content in muscle [ 31- 33].
L-CL helped grow the strains, carried out the microarray studies, conducted the statistical and clustering analyses, and helped draft the manuscript.
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We also need to consider that the microarray study conducted in Aedes [51] was carried out using the insect midgut and not the FM, tissues with very different functions and therefore with distinct metabolic demands.
Quantitative-PCR experiments were performed to; 1) validate the high throughput platform using the same material described in microarray study conducted by Hansen et al. study [ 16]; 2) extend the gene expression study with our newly designed experimental set up.
Furthermore, a gene microarray study conducted in autopsied hippocampal tissue from human AD patients (Blalock et al., 2004) found that multiple genes encoding proteins involved in ER receptor function, or in protein folding and chaperoning, which are also mediated in part by the ER, were down-regulated in incipient AD.
The resulting phenotypes were characterized and microarray studies were conducted on 24 hpf zebrafish embryos microinjected with the most potent of the two MOs, prp2-MO2.
To compare gene expression level between wild-type and Meig1-globally deficient mice in the testis, DNA microarray studies were conducted.
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