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Age, sex, and genetic strain of mice were based on previous data, in which the time course of fracture healing had been established by both histological and selected candidate gene assessment [8] [11].

Disease activity scores for DSS treated mice were based on the cumulative scores (0 10) from 3 different parameters: Stool consistency (0 = normal, 1 = soft but still formed, 2 = very soft, 3 = diarrhea), presence of blood in stool (0 = negative heamocccult, 1 = positive hemoccult, 2 = blood traces visible in stool, 3 = rectal bleeding) and histological changes (0 4).

RGS5-deficient mice were based on a C57BL/6 background.

Its first useful applications in mice were based on a combination of temporal and spatial regulation [ 47- 49].

Since most successful enhancer traps in Drosophila and mice were based on truncated or weak promoters, we decided to attenuate the S1EF1α promoter by removing sequences upstream of Bst1107I (S2EF1α) and EcoRI (S3EF1α) restriction enzyme sites.

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During the training phase, although the radiance of the red target was greater than that of the green, the reduced sensitivity of all photopigments (including the introduced L-opsin) at the longer wavelengths meant that the green target was calculated to appear "brighter" irrespective of whether the mice were basing their decision on the activity of cones, rods, or melanopsin.

Swiss Albino mice is based on affinity and rapid higher antibody response during the efficacy studies.

The rejuvenating treatment given to the mice was based on a technique that has previously been used to "rewind" adult cells, such as skin cells, back into powerful stem cells, very similar to those seen in embryos.

Dose evaluation regarding indometacin LD50 50 mg/kg in mice is based on a 14-days mortality response.

Our choice for female mice was based on recent study describing that the estimated new cases of colon cancer in 2009 was predicted to be higher in females compared to males [60].

Conditions of use (COU) for the mice are based on community standards and are identical to the COU currently covering mice from The Jackson Laboratory.

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