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The rejuvenating treatment given to the mice was based on a technique that has previously been used to "rewind" adult cells, such as skin cells, back into powerful stem cells, very similar to those seen in embryos.
Our choice for female mice was based on recent study describing that the estimated new cases of colon cancer in 2009 was predicted to be higher in females compared to males [60].
The targeting vector to generate miR-9 sponge transgenic mice was based on pROSA26-1 bearing 5.5-kb homology to the murine ROSA26 locus (R26) (Soriano, 1999).
Apart from isolated cases or outbreaks of LCMV infection associated with direct contact with laboratory rodent colonies, evidence for direct epidemiologic links between human cases and wild mice was based on virus isolation and antigenic relationships.
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Swiss Albino mice is based on affinity and rapid higher antibody response during the efficacy studies.
Dose evaluation regarding indometacin LD50 50 mg/kg in mice is based on a 14-days mortality response.
Age, sex, and genetic strain of mice were based on previous data, in which the time course of fracture healing had been established by both histological and selected candidate gene assessment [8] [11].
Disease activity scores for DSS treated mice were based on the cumulative scores (0 10) from 3 different parameters: Stool consistency (0 = normal, 1 = soft but still formed, 2 = very soft, 3 = diarrhea), presence of blood in stool (0 = negative heamocccult, 1 = positive hemoccult, 2 = blood traces visible in stool, 3 = rectal bleeding) and histological changes (0 4).
RGS5-deficient mice were based on a C57BL/6 background.
Its first useful applications in mice were based on a combination of temporal and spatial regulation [ 47- 49].
Conditions of use (COU) for the mice are based on community standards and are identical to the COU currently covering mice from The Jackson Laboratory.
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