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Day 12 Wt mice show clear expression of Id1 positive ECs, whereas CXCR6−/− mice do not (400×, Figure  6A).

By P13 Rac1N/Rac3KO double KO mice show clear neurological symptoms [ 14] and reduced body weight when compared with control littermates.

By P13 Rac1N/Rac3KO double KO mice show clear neurological symptoms [ 14], are smaller than control littermates (data not shown), and reveal a lower body weight (Fig. 1A).

They can induce apoptosis, but also have additional functions because p63−/− and p73−/− knockout mice show clear developmental defects, in contrast to p53−/− null mice which are viable and develop normally.

Because the FVB/Ant strain is pigmented and devoid of the genetic predisposition to retinal degeneration of the FVB/N strain, these mice show clear visual evoked potential in the presence of normal eye histology and improved performance in the Morris water maze test (Errijgers et al. 2007).

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Interestingly, the skin of caspase-8 knockout mice shows clear signs of hyperproliferation, particularly through the basal and spinous layers (Figure 1A).

Strikingly, the size as well as the histology of spleens derived from RBP-JK5/G-CSF+/− mice was comparable to control animals, while RBP-JK5 mice showed clear splenomegaly with loss of the white and red pulp (Figure 6C).

Representative histological sections from C. jejuni-associated IL-10−/−; NF-κBEGFP mice showed clear signs of inflammation after 14 days with crypt hyperplasia, goblet cell depletion, immune cell infiltration and ulcers.

Aortas from 4-week-old +/ Col3a1▵ mice showed clear abnormalities compared with +/+ controls.

After tamoxifen treatment, adult CAG-Cre-ERTM R26R reporter miCAG-Cre-ERTM R26Rnduction CAG-Cre-ERTM R26Re activity in motoreporters in the lumice showed clear winduction± 3.9% mofor neurons positive for the β-galaCresidase blue recombinaseoduct 5,5'-dibromo-4,4'-dichloro-indigo.

More importantly, 30 min after the third IL-33 challenge, WT but not ST2−/− or IL4Rα−/− mice showed clear signs of shock (piloerection, prostration, reduced response to stimuli), with a rapid reduction in body temperature lasting for about 15 min before returning to normal (Fig. 5C), and a substantial increase in serum histamine levels (Fig. 5D).

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