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The decrease in tumor staining, a poor nuclear-to-cytoplasmic ratio, and the loose structure in the [D]-K3H3L9 treated mice indicates a massive tumor cell death.

The use of an osmotic pump to deliver this compound in mice indicates a poor pharmacokinetic profile and highlights the need for in vivo stable SphK1 selective inhibitors.

The imbalance in redox status observed in the livers of Cmah-null mice indicates a nutritional oxidative stress phenomenon, which is caused by excessive and prolonged consumption of metabolic fuels (carbohydrates and lipids) and/or inadequate supply of dietary antioxidants.

Whether the observed increase in IL-10 secretion by Tregs from old mice indicates a shift in Treg subset populations as part of the aging process, is an intriguing question that remains to be examined.

The presence of distinct embryonic lethal phenotypes in homozygous and LVOT phenotypes in heterozygous Matr3Gt-ex13 mice indicates a sensitive dependence on Matr3 gene dosage for different developmental processes.

The fact that unlike two other core paraspeckle proteins, PSP1 is not detected in final products of FUS aggregation in neurons of transgenic mice indicates a certain selectivity of paraspeckle protein co-aggregation and not mere entrapment of entire paraspeckles.

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Since the learning curve (training sessions) represents a compound effect of acquisition and retention, with a dominant influence from the acquisition, a normal learning curve in hip-eEF-2K-tg mice indicates an intact acquisition process.

On the other hand, investigation concerning certain fibrotic diseases using Smad3-null mice indicates an essential role of Smad3 in EMT (95).

Six cycles of O/R reduced infarct size 24 h later in WT mice, indicating a late PC effect.

The biocompatibility was examined in mice indicating a good tolerance upon subcutaneous implantation with only a mild inflammatory response.

In addition, the incidence of metastasis was also increased in ATM−/− Gadd45a−/− mice, indicating a role of Gadd45a in the prognosis of hematopoietic malignancies.

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