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The course of the brain SUV curve (Figure 6A) in WT mice demonstrates a fast uptake in the brain, followed by a rapid wash out of the brain, resulting in an SUV of 0.25 already 1 min after the tracer injection, while in KO and pretreated WT mice also a fast uptake was observed, followed by an accumulation in the brain of the tracer combined with a slow efflux.
Electroretinography performed in MPS IIIB mice demonstrates a loss of rod function that correlates with diffuse retinal pathology including photoreceptor degeneration and vacuolar inclusions in the retinal pigmented epithelium.
Unaltered ARH circuitry in the LiGHRKO mice demonstrates a specific role of GH action in hypothalamic development.
The postnatal lethality of Ptbp2-EmxKO mice demonstrates a continued requirement for PTBP2 to allow neuronal maturation and survival in the developing postnatal cortex.
The significant reduction in numbers of TUNEL-positive cells in hyperoxia-treated A2−/− mice demonstrates a role for A2 in hyperoxia-induced retinal neurodegeneration.
High throughput gene expression analysis in the cerebellum of a large number of Ts1Cje and euploid mice demonstrates a prevailing gene dosage effect of trisomy and a limited secondary effect across postnatal development.
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Reduction of apoE deposition in Aβ12-28P-treated Aβ12-28P-treated Aβ12-28P-treatedechanismicerough which demonstratesf the anoE/additionaltion mechanismorathroughlaque formation and associated neurodegeneration.
C57BL/6 mice demonstrated a distinct profile of microbiome file in gut.
In addition, OX40 ligand-deficient mice demonstrated a decreased risk of allograft rejection when transplanted with wild-type donor corneas.
Data from PKCδ −/− mice demonstrate a role for PKCδ in the execution of DNA damage-induced and physiologic apoptosis.
Creating revertant viruses and subsequent neurovirulence test on mice demonstrated a major effect of residue 138 and cooperatively effect of residue 279 (Yang et al., 2017).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com