Exact(16)
Pharmacokinetics data in normal mice indicate a higher initial influx into the brain, followed by clearance due to a lack of targeted plaques within the brains of normal mice, an important factor that could determine critical target/background ratios.
On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease.
Therefore, the reduced transcript levels of all these genes in the striatum of old A53T-SNCA overexpressing mice indicate a progressively diminished postsynaptic DA response.
Studies using PAR deficient mice indicate a duality of PAR function depending on the context with both pro- and anti-inflammatory roles being reported.
The strikingly preserved agonist-induced NO dependent vasodilatation of resistance vessels from Apoe−/−/IL-1R1−/− mice compared to Apoe−/− in both diet groups as well as the greater contraction in response to L-NAME in the fat-fed Apoe−/−/IL-1R1−/− mice indicate a fundamental increase in bioavailable vessel wall nitric oxide as a result of selective loss of IL-1 signaling.
In summary, the histopathologic findings in these mice indicate a clonal myeloproliferative disorder with dysplastic features.
Similar(44)
Studies of cigarette smoke-induced accumulation of lung DCs in mice indicate an IL-1 dependent IL-1 dependent0].
In this regard, several studies in mice indicate an important role of B cells producing IL-10 in controlling autoimmunity [ 147].
Six cycles of O/R reduced infarct size 24 h later in WT mice, indicating a late PC effect.
The biocompatibility was examined in mice indicating a good tolerance upon subcutaneous implantation with only a mild inflammatory response.
In addition, the incidence of metastasis was also increased in ATM−/− Gadd45a−/− mice, indicating a role of Gadd45a in the prognosis of hematopoietic malignancies.
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