Sentence examples for mice has proven from inspiring English sources

Nevertheless, modeling a complex, multigenic disease like psoriasis in mice has proven to be extremely challenging and is associated with significant limitations.

Genome-wide haplotype association in inbred strains of mice has proven to be a useful experimental strategy to detect loci that regulate complex traits [37], [38].

The use of dense SNP maps in laboratory inbred mice has proven successful in the refinement of previous QTL regions and the identification of new genetic determinants of complex traits [4] [8].

The use of T-cell receptor transgenic (TCR-tg) mice has proven a powerful tool for investigating the nature of self-reactive T cells in tolerance and autoimmunity [ 3].

Published: May 15 , 2008Retroviral insertional mutagenesis in mice has proven to be an efficient tool for identification of novel cancer genes, providing a valuable complement to the study of human tumors.

The use of mice has proven useful to further our understanding of the events leading up to parturition owing to the ease with which the mouse genome can be manipulated.

Although the NOD-scid Il2rg − / − mice are highly immunodeficient and humanization on these mice has proved to be a powerful and valuable model to in vivo study of human disease, there are still some obvious defects in their application for generating humanized mice.

Given the limitations of studying patients, research with mice has proved invaluable for understanding the roles of cilia in health and disease.

The use of MCF-7 cells transfected with human aromatase gene (MCF-7Ca) and implanted into athymic nude mice has proved to be an effective in vivo model for predicting clinical results with AIs [ 61, 96, 97].

Therefore, in vivo diagnosis of AD pathology in the brains of these mice has proved to be challenging and most often can only be accomplished postmortem or through laborious learning and memory tests that are not only challenging but also quite often subjective.

The embryos of laboratory mice have proven to be too different to shed much further light on the arcane genetics of early human development, they said.