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Genetic engineering in mice has provided much information about gene function in renal health and disease.
The use of genetically engineered mice has provided substantial new insights into the functional organization of the striatum.
The ability to genetically engineer specific gene 'knock-out' mice has provided a powerful tool for investigating the various mechanisms that contribute to the pathogenesis of pulmonary arterial hypertension (PAH).
The delineation of GI epithelial patterning mechanisms in mice has provided fundamental knowledge to guide the development and refinement of three-dimensional GI organotypic culture models such as those derived from directed differentiation of human pluripotent stem cells and those derived directly from human tissue samples.
The introduction of genetically engineered mice has provided potentially more specific modelling opportunities.
Investigation of Vav2 and Vav3 single or double knockout mice has provided more information about the functional roles of these proteins in the nervous system.
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To date, studies using genetically engineered mice have provided some information on subtype-related functions of the CNS α1-ARs.
Background & Aims: Gene-targeted and transgenic mice have provided profound insights into the genetic control of intestinal development and differentiation.
These data together with TPH2 knockout mice have provided additional insights into the role of TPH enzymes in regulating brain-specific serotonin deficiency [47 49].
Studies on mice have provided evidence of the role of osteocalcin in increasing testosterone production in males by feedforward loop [29].
Recent studies on genetically engineered Kir6.2 knockout mice have provided a better understanding of the physiological and pathophysiological roles of Kir6.2-containing KATP channels.
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