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However, manipulation of myostatin expression in transgenic and knockout mice has generated conflicting results.
We believe that the modulation of the diet composition in Pank2 knockout mice has generated a useful model system in which to test not only pantethine, but also additional compounds, which could be beneficial for patients.
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By this time, these mice have generated high titers of B. parapertussis-specific antibodies [24].
ENU-induced mutations in mice had generated the Svc mouse that is small and has vacuolar cataracts [29] resulting from a missense mutation in the Col4a1 gene that encodes collagen IV [20].
Conditional inactivation of lkb1 in a number of tissues in mice have generated tumours in breast, pancreas, prostate, skin and bone.
The study of PANK2 function is complex, and efforts to generate animal models of disease by knocking out the gene in flies and mice have generated incomplete phenotypes, lacking signs of neurodegeneration and/or of brain iron accumulation (5, 6).
Extensive histopathological studies and investigations on the initiation of atherosclerosis in transgenic mice have generated a quite detailed picture of the development of atherosclerosis in the various stages of disease [ 56– 63].
For example, small RNA-cDNA libraries from the ovaries of 2-wk-old and adult mice have generated a number of miRNAs with potential role in ovarian function [ 24].
This mouse model has generated fundamental principles for an effective vaccination strategy.
Like Kras loxP-STOP-loxP-G12D mice, investigators have generated mice in which Kras G12D is regulated by a transcriptional terminator sequence flanked by FRT sites in the endogenous promoter (Kras FRT-STOP-FRT-G12D) (Young et al., 2011).
To enable well-powered studies in mice, we have generated high-density genotypes for ∼175 inbred strains of mice using the Mouse Diversity Array.
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