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In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption and sedation.
In the last few years, electrophysiological study of genetically engineered mice has demonstrated the topical role of several genes encoding calcium-binding proteins (calretinin, calbindin, parvalbumin).
Fate tracking of alveolar epithelial cells in genetically modified mice has demonstrated that mesenchymal cells arising during the progression of pulmonary fibrosis can originate from epithelial cells [61, 69, 70].
Recently, a study in mice has demonstrated an unique pattern of regulation for CCL25 expression [35].
Generation of Math6 null mice has demonstrated that, in addition to its probable roles in organ and tissue differentiation, Math6 is involved in early embryogenesis.
Salmonella persistence model in mice has demonstrated that although majority of the bacteria are intracellular, there will be some bacteria in the extracellular compartment also [18].
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Previous studies in flies and mice have demonstrated that null mutations in mnb cause embryonic lethality15,43.
First, studies of COMT knockout mice have demonstrated that dopamine levels are increased in the prefrontal cortex of these mice under varying conditions, but not in the striatum (Gogos et al, 1998; Huotari et al, 2002).
Recent studies of CB1 knockout mice have demonstrated that the genetic deletion of the CB1 receptor leads to increased anxiety in several well-studied measures (Haller et al, 2002, 2004a, 2004b; Martin et al, 2002).
Recent experiments in mice have demonstrated that the expansion of a specific clone of T cells in response to cognate antigen obeys a striking inverse power law with respect to the initial number of T cells.
Ultimately, both subcutaneous and orthotropic liver tumor models in mice have demonstrated that the proposed Janus nano-bullets imposed remarkable suppression of the tumor growth and significantly reduced systematic toxicity.
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