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PGC-1α knockout mice exhibit multiple metabolic defects, such as obesity, neurodegeneration and cardiomyopathy [9], [10].
Previous reports have shown that CXCR4-null mice exhibit multiple developmental defects and die perinatally [3], [4], [29].
CPE KO mice exhibit multiple endocrinopathies leading to obesity, diabetes, and infertility [ 19]; however, how CPE promotes tumor progression is largely unknown.
This is clearly exemplified in the case of p73, since endogenous p73 protein levels are much lower than those of p63, yet p73 knockout cells and mice exhibit multiple phenotypes.
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Previously reported Mib1−/− mice exhibited multiple defects in neurogenesis, somitogenesis, vasculogenesis, and cardiogenesis [13].
All SKOV-3-inoculated mice exhibited multiple, variably-sized infiltrative tan, solid tumor nodules distributed throughout the peritoneum by 4 weeks post inoculation (p.i).
We found that ΔT mice exhibited multiple developmental defects, with not only G-protein-independent but also G-protein-dependent signaling events completely abolished, despite ΔT's ability to still associate with G-proteins.
Pilocarpine-treated mice exhibited multiple daily spontaneous recurrent tonic-clonic seizures (SRSs) over a six-week period (eight weeks after pilocarpine) before behavioral testing.
Thus, Daam1 gt/gt mice generally exhibit multiple heart defects, including ventricular non-compaction, double outlet right ventricles and ventricular septal defects (Li et al., 2011).
We have recently reported that progeroid Zmpste24−/− mice, which exhibit multiple defects that phenocopy Hutchinson-Gilford progeria syndrome, show a profound dysregulation of somatotropic axis, mainly characterized by the occurrence of very high circulating levels of growth hormone (GH) and a drastic reduction in insulin-like growth factor-1 (IGF-1).
Nijnik et al. found that LIG4Y288C mice (a mouse model for human LIG4 syndrome) exhibit multiple defects in lymphocyte development and a hypomorphic LIG4 mutation can confer strong predisposition to lymphoid malignancies [ 30].
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