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HO mice exhibit mild hepatopathy but, in contrast to previous models of classical homocystinuria, do not incur hepatic steatosis, fibrosis, or neonatal death with approximately 90% of HO mice living for at least 6 months.
Here, we analyzed the phenotype of IRE1α conditional knockout mice and found that IRE1α-deficient mice exhibit mild hypoinsulinemia, hyperglycemia, and a low-weight trend.
Consistent with this, Wnt11 null mice exhibit mild renal hypoplasia and a reduction in Gdnf expression [20] almost identical to that observed in Ptc1−/−UB mutants.
Cyln2+/− mice exhibit mild growth retardation, mild brain abnormality, attenuated contextual fear, and reduced synaptic plasticity and motor function (Hoogenraad et al, 2002).
In contrast, Coq9 Q95X mice exhibit mild CoQ deficiency manifesting with reduction in CI+III activity and mitochondrial respiration in skeletal muscle, and late-onset mild mitochondrial myopathy, which does not respond to 2,4-diHB.
The genetically engineered null mutant for this gene has a very similar phenotype compared to the one that we observed in our animals: mutant mice exhibit mild to severe spasms of the hind limbs, abnormal hind limb reflexes, and difficulty righting [ 13, 14].
Similar(54)
Consistent with these results, natalizumab-treated mice and both CD4+ T-cell-specific and CD19+ B-cell-specific ITGA4 knockout mice exhibit milder EAE disease.
In this study, we first found that following BLM injection, the histology of the lungs from Ninj1 KO mice exhibited mild inflammation and fibrotic phenotype, as compared to the WT mice.
Although the antisera from the immunized mice exhibited mild neutralizing potency to HIV-1 isolates HXB2 and JRFL, the affinity purified mucosal ELDKWA-epitope specific antibodies could block the transcytosis of cell-free CNE3 (a primary isolate of subtype CRF01_AE) in human tight epithelial models.
GRK5-KO mice exhibited mild spontaneous hypothermia as well as pronounced behavioral supersensitivity upon challenge with the nonselective muscarinic agonist oxotremorine.
Following systemic administration of glucose, both male and female Tsc1−/− mice exhibited mild but significant glucose intolerance compared to Tsc1+/+ mice (Figure 1C).
Related(20)
mice exhibit minimal
mice exhibit modest
mice exhibits mild
mice exhibit moderate
mice exhibit exaggerated
mice exhibit spermatogenic
mice exhibit parasagittally-restricted
mice exhibit premature
mice exhibit degenerative
mice exhibit germinal
mice exhibit severe
mice show mild
mice exhibit multiple
mice exhibit similar
mice exhibit distorted
mice exhibit gender-bias
mice exhibit mania-like
mice exhibit obese
mice exhibit hematopoietic
mice exhibit myopathy
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