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In addition, cIAP2-deficient mice exhibit profound resistance to LPS-induced sepsis.
Together, these results suggest that Mwk mice exhibit profound dendritic and synaptic impairments during development as well as in adulthood.
Setd2 −/− mice exhibit profound vascular defects and die at E10.5 E11.5 (Hu et al., 2010), while Setd2 −/− are defective for differentiation toward endoderm (Zhang et al., 2014).
While the nature of this genetic influence is unknown, both db/db and ob/ob mice exhibit profound resistance to insulin.
Consistent with this, CD28-negative transgenic mice exhibit profound defects in mitogenic responses (Shahinian et al, 1993), and germinal centres are not formed in response to immunisation (Ferguson et al, 1996).
Functional compensation for the loss of ILDR1 in ILDR1 null mice does not occur since Ildr1 homozygous mutant mice exhibit profound deafness suggesting a unique function for ILDR1 at tTJs.
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Older AD and db/AD mice exhibited profound aneurysm pathology and db/AD mice had small strokes.
This contrasts with the result that R26CT-CRE mice exhibited profound spatial working memory deficits at 8 months of age.
In addition, MORE-DG-null mice exhibited profound muscle weakness and muscular dystrophy was present at birth, reminiscent of a secondary dystroglycanopathy phenotype (see next paragraph) [ 39].
Hdac1Δ/Δep Hdac2Δ/+ep mice exhibited profound changes in the development of all three epidermal lineages resulting in epidermal hyperproliferation and hyperkeratosis, accompanied by hair loss and SG enlargement.
We found that the Per2-mutant mice exhibited profound deficits in the longer-term recall, but not in the acquisition or short-term recall, of trace-fear conditioning.
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mice exhibit spermatogenic
mice demonstrate profound
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mice exhibit germinal
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mice exhibit mania-like
mice exhibit obese
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mice exhibit myopathy
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