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Interestingly, EGR3-deficient mice exhibit several neuromuscular defects including gait ataxia and scoliosis [36], symptoms which resemble those exhibited by Friedreich ataxia patients.
In the absence of 4HT, R26CreER Z/AP mice typically exhibit no AP+ cells per retina, whereas R26CreER Brn3aCKOAP/+ and R26CreER Brn3bCKOAP/+ mice exhibit several hundred AP+ RGCs per retina.
Moreover, giant GH transgenic mice exhibit several characteristic features of premature aging [ 36].
These mice exhibit several features of human ILC, including invasive, metastatic mammary tumours that develop in a lactation-independent manner.
We have recently found that old male Casp2− / − mice exhibit several traits commonly observed in premature aging animals, including a 10%% shortened maximum lifespan and severe age-related osteoporosis (Zhang et al. 2007).
These BK5.ATF3 mice exhibit several epidermal phenotypes, including a gross hyperplasia of the outer root sheath cells of the hair follicles, resulting in abnormal hair growth, and a milder hyperplasia of the interfollicular epidermis [ 19].
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Middle-agedDgat1-/ mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity.
Middle-aged Dgat1−/− mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity.
In this work, we demonstrated that Sirh7/Ldoc1 KO mice exhibited several abnormalities, such as structural and endocrinological defects in the placenta, delayed parturition and a low weaning rate.
OPG-deficient mice exhibit severe osteoporosis [ 14].
Interestingly, ADCYAP1 knockout (KO) mice were shown to exhibit several bipolar disorder-related phenotypes (Hashimoto et al, 2009; Kawaguchi et al, 2003).
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