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Myo-CELFΔ mice exhibit modest changes in CELF-mediated alternative splicing in skeletal muscle, accompanied by a reduction of endomysial and perimysial spaces, an increase in fiber size variability, and an increase in slow twitch muscle fibers.
These studies revealed that Nrarp−/− mice exhibit modest postnatal growth retardation (Fig. 7).
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Compared with C57BL/6 mice, BALB/c mice exhibited modest resistance to infection after deposition of 104 CFU/lung.
Although Con and KO mice showed equivalent basal serum-free fatty acid (FFA) and glycerol levels (Fig 3L), KO mice exhibited modest increases in circulating FFA and glycerols in response to intraperitoneal (i.p).
Db/db mice with Angiotensin II-induced hypertension developed interstitial lesions and albuminuria but not mesangial matrix expansion, while nephrectomized db/db mice exhibited modest mesangial expansion and interstitial fibrosis, but not significant albuminuria.
TRPV4 knockout mice also exhibited modest defects in heat-evoked pain sensation, though this phenotype was virtually absent in TRPV3/TRPV4 double knockout mice.
KO mice also exhibited modest thickening of the articular cartilage (Supplementary Figure S1e).
However, our results show that Bcl-2 Tg mice may develop autoimmunity at low penetrance, as some mice exhibited a modest accumulation of activated T cells and autoantibodies.
However, KO mice exhibited a modest reduction in the levels of this molecule, which was severely down-regulated in anti IL-7 antibody treated KO mice (Figure 2A).
The leukemic cells in the spleens of leukemic mice exhibited a modest increase (0.3- to 8-fold) in tax mRNA expression compared with splenocytes from disease-free transgenic mice (Figure 1B).
DKO mice exhibited a modest elevation in the expression of ABC5 and ABCG8, the 2 ATP-binding cassette transporters that promote cholesterol secretion.
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