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Fmr1 knock-out mice exhibit exaggerated translation of target mRNAs at the synapse.
In studies aimed at identifying the key effector molecules and events responsible for the FGF-induced growth-arrest, we had previously established that it requires the function of the p107 and p130 members of Retinoblastoma (Rb) family, but not of pRb [4], in line with the observation that p107/p130 knockout mice exhibit exaggerated chondrocyte proliferation [5].
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Furthermore, C57BL/6J adult mice exposed to hyperoxia as neonates and recovered in RA exhibit exaggerated pulmonary immune responses following influenza virus infection [ 22].
The null heterozygotes exhibited exaggerated conditioned fear, more pronounced avoidance of well-lit environments, and increased response to stress.
These data showed that CD36−/− mice exhibit higher levels of plasma cholesterol than WT mice and this difference is exaggerated upon feeding a cholesterol rich diet.
IL-6 deficient mice exhibit reduced expression of AVP [187].
It was Christmas Eve of 2012 when Ramirez first saw the mice exhibit this response.
Other mutant mice exhibit parasagittally-restricted ectopias.
AC3 knock out mice exhibit obese when they age.
However, AC3−/− mice exhibit normal ß-adrenergic stimulation of lipolysis.
Like Zeb1 heterozygotes, adult PPCD1 mice exhibit synechiae.
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