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In 2003, researchers from two laboratories found that fat tissue from obese mice contained an abnormally large number of macrophages, immune cells that contribute to inflammation.
Mouse embryonic fibroblasts (MEFs) derived from dlg mutant mice contained an increased number of multinucleated cells and showed reduced proliferation in culture.
Using this strategy, we observed that splenocyte cultures from Ad5.TRP-1-immunized mice contained an average of 0.06% CD4+ IFN-γ+ cells responding to TRP-164 78 TRP-164 781% in case of Ad5.EGFP-treated mice (Fig. 5C).
The reconstituting B cell repertoire in wild type mice contained an increased frequency of DNA-reactive B cells; in heavy chain transgenic mice, the reconstituting repertoire was characterized by an increased frequency of mature, high affinity DNA-reactive B cells and the mice expressed increased levels of serum anti-DNA antibodies.
Blood from pIpC-injected control and ILK KO mice contained an equal number of platelets.
We observed that both in vitro-generated and ex vivo-isolated MVs from MRL/lpr mice contained an increased amount of accessible (modified) chromatin compared to MVs from BALB/c mice.
Similar(54)
b Pleural lavage fluid from S. pneumoniae infected PAI-1−/− mice contained a significantly higher percentage of neutrophils than identically treated WT mice.
PLF from WT mice contained a greater bacterial load than TSP-1−/− mice after CLP.
The pancreas of orexin knockout mice contained a small quantity of OX1R compared to the pancreas of the wild type.
The pancreatic islet of C57BL/6 mice contained a significantly larger number of OX1R-immunoreactive cells compared to the mutant type.
The male reproductive organs of HdhQ150/Q150 mice contained a few cells in the testicular epithelium of the seminiferous tubules of the testis that had nuclear inclusions, the identity of which needs to be confirmed by appropriate histological staining.
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