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Moreover, further research using the lung tissues from same mice indicated an increased percentage of B16F10 cell available in the lung by flow cytometry.
In addition, studies that analyzed global gene expression in the left ventricle of MEF2C transgenic mice indicated an upregulation of genes encoding ion-handling and extracellular matrix-associated proteins[8], which might be involved in the deleterious effects of MEF2C activation.
In contrast to the well-defined abscesses present in the kidneys of infected immunocompetent mice (Fig 2), histopathological examination of kidney tissue from infected RAG−/− mice indicated an impaired capacity to develop abscesses (Fig 5B).
DOI: http://dx.doi.org/10.7554/eLife.05648.017 While WT mice efficiently eliminated infections, increased fecal excretion of bacteria at day10 post-infection in Nfkb2 −/− mice indicated an inadequacy in limiting local infection, thereby, correlating with the observed defects in the early innate inflammatory response in this knockout.
Oral fat tolerance tests performed with 5-week-old mice indicated an impaired fat absorption in Arfrp1 vil−/− mice: in contrast to controls (Arfrp1 flox/flox), Arfrp1 vil−/− mice failed to respond to a bolus of olive oil by an increase in plasma triacylglycerol (Fig. 2B).
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Indeed, increased expression of Pdk1 and Glut1 in rodΔVhl mice indicated a metabolic shift that may have resulted in reduced oxidative phosphorylation and thus reduced production of ATP in rods.
In a second part of the experiment, female mice indicated a preference for the complex mating calls over the simple ones -- a further indication that complex songs are an effective means of seduction.
Thus, the decreased miR-206 expression in SHP−/− mice indicated a secondary effect due to the loss of SHP repression.
Studies of knockout mice indicated a non-redundant role of CCL2 in modulating MLs infiltration during inflammation [40].
Compared to wild-type mice, the auditory brainstem response (ABR) of Slitrk6-KO mice indicated a mid-frequency range (8 16 kHz) hearing loss and reduction of the first ABR wave.
Furthermore, our assessment of polyclonal antibody isotypes in the sera from Omp3- and Omp7-immunised mice indicated a predisposition towards a Th1-driven immune response as demonstrated by an IgG2a/IgG1 ratio of >1 [24].
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