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These findings indicate that C. jejuni responses in IL-10−/− mice are unique to the biology of the microorganism and are not reproduced by other commensal/pathogenic bacteria studied so far in this model (E. coli, E. feacalis, H. hepaticus, B. vulgatus or P. fluorescens).

These mice are unique in that they cannot increase myelopoiesis in response to physiologic triggers, including tumors [ 25, 27].

Hence, L31 and L31/CD4-/ mice are unique to understand molecular pathways by which CD8+ T cells are involved in demyelination and axonal damage.

Therefore, PPARβ−/− mice are unique in that they display similar key metabolic and skeletal characteristics as in human T2DM patients, namely lower mechanical properties and higher cortical porosity in the absence of low BMD (5).

Moreover, PER2 S662G and PER2 S662D transgenic mice are unique because single amino-acid changes at this site can either shorten or lengthen the circadian period in a mutation-dependent manner, thus providing a unique model to understand how circadian period length affects cell cycle progression and tumorigenesis.

While our data are in broadly supportive of these other studies, the db/AD mice are unique in that they have Aβ plaques, very little vascular-associated Aβ, and profound underlying vascular abnormalities, even in the absence of a high-fat diet.

Similar(54)

In this regard, the vestibular dysfunction in Slitrk6-KO mice is unique.

The expression of ALDH1A1 in DN-p38αAF/+ mice is unique, however, in that it peaks at middle age and declines in the aged muscle.

In contrast to our findings in vitro, which corroborate other published findings, our inability to demonstrate a benefit for curcumin in diabetic nephropathy (DN) in DBA2J mice is unique among published studies in this field.

Nevertheless, the pattern seen in 03A-0241; Tg(tetL)1Bjd/J mise is unique to these mice, as it is not seen in carriers of other T2/GT2/tTA or T2/GT3/tTA insertions (with or without associated concatemers) when crossed to the Tg tetL 1Bjd/J strain (above and data not shown).

Hence, the deficient LPS and PMN migratory responses in the Mmp8-/ mouse are unique and reveal the singular importance of MMP-8 in these processes.

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