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Together with Thy1-GFP mice, in which mature dentate granule cells are specifically labeled, these groups of transgenic mice provide unique tools for studying dentate granule cells at different developmental stages.
In this way, our mice provide unique opportunities to reveal the long-term effects of FUS/TLS depletion in adults.
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Hence, the generation of ngr2 and ngr1/2 deletion mutant mice provides unique animal models that permit investigation into the relative contribution of these receptors in MAG-dependent neurite growth inhibition.
As ECE-2 has been implicated in Alzheimer's disease, the deficits in learning and memory in the KO mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition.
The Id2−/− mouse should provide unique opportunities to study the progression of neurodegenerative disorders involving the dopamine system.
Gene promoters fused to the firefly luciferase gene (luc) are useful for examining gene regulation in live transgenic mice and they provide unique views of functioning organs.
Using a pericyte-reporter mouse model, we provide unique evidence that regulator of G-protein signaling 5 expressing cells are activated pericytes that leave the blood vessel wall, proliferate and give rise to microglial cells after ischemic brain injury.
These overlaps have led many investigators to conclude that Fmr1 knockout mice provide a unique opportunity to identify interventions that affect autistic-like behaviors [12] [14].
These knockout mice provide a unique platform for future studies to identify the role of CA125/MUC16 in organ homeostasis and ovarian cancer.
Furthermore, Ehd3 /–; Ehd4–/– mice provide a unique model to elucidate mechanisms of glomerular endothelial injury which is observed in a wide variety of human renal and extra-renal diseases.
The γ1 knockout mice provide a unique resource to understand the function of this protein in myotubes in molecular detail.
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