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Induced levels of cAMP in platelets and in brains of fmr1 knockout mice are substantially reduced.

Alternatively, since the basal freezing rates in patDp/+ mice are substantially higher before stress conditioning, these unusual phenotypes could represent decreased locomotor activity and/or increased novelty-induced anxiety.

Furthermore, IL-17 receptor deficient mice are substantially blocked in development of streptococcal cell wall induced arthritis [ 103].

The objective of the present study was to determine why XY Sry- female mice are substantially less fertile than XO female mice: our working hypothesis was that this was due to a deleterious effect of Y gene expression in oocytes.

The Ncr1gfp/gfp mice and the other mice are substantially different at the DNA, RNA, and protein levels 9, 50, 51, and this might be the cause of the phenotypic differences observed among the various mice.

Both the frequency of mutated sequences and the mutation rate for splenic B-1a samples from 2 month old mice are substantially lower than those in 4 6 month old mice, further supporting that the SHM in the splenic B-1a IgVH is an accumulative process.

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Biochemical markers showed that livers, hearts, and kidneys of treated mice were substantially unaffected by the administration of 3, despite the presence of the potentially toxic nitro group.

Expression of osteoclasts in osteopetrotic (op/op) mice is substantially reduced by the absence of functional macrophage colony-stimulating factor (M-CSF).

In addition, the viral burden in the CD62L+ CD8 T cell transferred mice was substantially lower compared to CD62L− CD8 T cell transferred mice (Fig. 4c).

In comparison, Mn2+ accumulation from 8 hr to 26 hr observed in WT mice was substantially more widespread (e.g. cortical regions, ipsilateral and contralateral TH, and periaqueductal gray areas) than that observed in DAT KO mice.

On the other hand, PrPSc deposition profiles in Tga20 mice were substantially different between the strains 22L, ME7 and RML and did not correlate with the level of PrPC overexpression in these mice (Tables 1, 5 and Fig. 5).

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