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Moreover, humoral immune responses in these mice are dramatically impaired.
Normal mice have spontaneously high levels of alternation, whereas hippocampal-lesioned mice are dramatically impaired.
Remarkably, these mice exhibit significant increases in muscle mass despite the fact that the circulating levels of myostatin protein in these mice are dramatically increased compared to wild type mice.
Interestingly, disease morbidity and mortality in these F1 mice are dramatically reduced by neutralizing anti IL-6 receptor anti IL-6(Mihareceptor. 1998), antibodyt associated with reduced IgG (auto-) antibody production.
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Brain ascorbic acid content in embryonal SVCT2-deficient mice was dramatically reduced [38].
Moreover, muscle weights in either F66/Mstn+/− or F66/Mstn−/− mice were dramatically higher than in Mstn−/− mice lacking the F66 transgene.
Furthermore, blood vessel formation in NOX1-deficient mice was dramatically reduced in response to angiogenic factors and in tumors.
The number of neurons with intense Tph2 immunofluorescence in the raphe nuclei of Lmx1b iCKO mice was dramatically reduced compared with control mice (Figure 4).
The elevated IOP of 7-week-old Vav2−/−Vav3−/− mice was dramatically reduced by ocular hypotensives used in humans, such as latanoprost, a prostaglandin analogue (Figure S4A).
More interestingly, the total level of TrkB phosphorylation in tat-cyclotraxin-B-treated mice was dramatically decreased as compared to saline or tat-empty-treated animals (Fig. 7B).
Combining these findings with our data directly showing that intercellular GJ-mediated 2-NBDG diffusion among supporting cells in the Cx30 null mutant mice was dramatically reduced (Figs.
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