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The reason is because of the great deal of effort put into the former two models and that the studies in humans and mice are considerably more relevant to our own health.
In addition, Mstn−/− mice are considerably more muscular than constitutively active Akt1 mice, have a higher number of fast glycolytic fibers 8, 16, and have less adipose mass even on standard chow [17], [18].
Similarly, serum levels of IL-6 in TNF transgenic animals (TNF-knockout mice) are considerably elevated, and these animals have progressive and aggressively destructive arthritis [ 9].
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Treated with DFP and DFO + DFP mice were considerably increased in lipid peroxidative markers.
Interestingly, subordinate mice were considerably more often involved in self-directed Grooming activity than dominants.
The adipocytes from AC3−/− mice were considerably larger than those from AC3+/+ mice (Figure 3A and 3B).
Therefore, the incidence of osteogenic tumors in Pol β Tg mice is considerably higher than incidences cited in the literature.
The 39% incidence of proliferative duodenal lesions in the Pol β Tg mice is considerably higher than previously reported incidences of 4% [63] and 21% [64] in aged C57BL mice.
The percentage of γδ T cells expressing IL-17 in WT infected mice was considerably higher than the percentage of CD4+ T cells.
Although there were no changes in the expression levels of any of the three NOS isoforms, NOS activity in neocortex of mutant mice was considerably increased compared with control neocortex.
These mice were considerably smaller than normal (Figure 1B), had persistent diarrhea and rectal bleeding, and died prematurely from the first weeks of life to about 9 months maximum; all animals died with rectal prolapse.
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