Sentence examples for mice have substantially from inspiring English sources

5HTT-/ mice have substantially lowered circulating 5-HT[ 8], and by analogy to 5HTT-/ rats likely plasma 5-HT[ 15], which should result in decreased 5-HT-derived tone and thus protection against IPAH.

Consistent with the MEF data, Nfkb1 +/+ mice have substantially more apoptotic cells in the cortex and dentate gyrus than Nfkb1 −/− mice as demonstrated by both TUNEL analysis (Fig. 4C) and caspase 3 staining (Fig. Supplemental S2).

Dosing was terminated after 10 days due to health crisis seen with vTK+ mice that received 50 and 100 mg/kg GCV doses; only these mice had substantially elevated serum aminotransferases.

However, the Coro-1A−/− mice had substantially fewer cells in their lymph nodes (LNs) and, generally, increased numbers of total thymocytes compared with Coro-1A+/− and WT controls (Tables 1 and S1).

In mast cell null mice, reconstitution with Tnf−/− mast cells showed a signaling defect that affects mast cell EC interaction, whereas TNF-α receptor knockout (Tnfr1−/−) mice had substantially reduced mRNA and protein levels of P-selectin, E-selectin, ICAM-1, and VCAM-1 during delayed-type hypersensitivity response elicitation [35].

Femurs from 5-LOKO mice had substantially better mechanical properties after 1 month of healing than did control mice.

Further examination of frozen joint sections by immunofluorescence microscopy indicated that IL-10−/− mice had substantially increased IL-17-producing macrophages in synovial tissue compared with WT mice.

Macrophages from A0 and A0H0 mice had substantially more LDs compared with macrophages from Wt and H0 mice (Fig. 2C, D).

By contrast, rTgTauEC x APP/PS1 mice had substantially more human tau positive DG granule cells (approximately 20-fold increase relative to rTgTauEC, p < 0.05).

We found that Bid mice had substantially elevated LS parasite burden similar to the increase observed when inhibiting all apoptosis with Q-VD-OPh pan-caspase inhibitor treatment.

At 24 hours after infection, PAR-1 KO mice had substantially lower plasma levels of TNF-α and MCP-1 (P <0.001) and a trend toward lower IL-6 concentrations (P = 0.08) when compared with WT mice.