Second, gD2-antibody responses provide a robust index of protective immunity against HSV-2 when mice are immunized with a live HSV-2 virus, but this is not the case when mice are immunized with an HSV-2 gD subunit vaccine (unpublished data of W. Halford).
Interestingly, when wild-type mice are immunized with heat killed Listeria monocytogenes (HKLM), protective immunity is not conferred in them, but a higher level of protection is rendered if the mice are depleted in CD4 cells [ 60].
As demonstrated above and reported previously [8], [11], [12], inhibition of tumour outgrowth is regularly 95 100% when BALB/c mice are immunized with Her2/neu-cVLPs two weeks prior to challenge.
Interestingly, when mice are immunized using PsaA-BLyS and boosted with PsaA, the TACI KO do not respond well when either primary or secondary responses are measured.
In this model for RA, mice are immunized with CII mixed with Freund's complete adjuvant, and are challenged 3 weeks later with CII alone.
In this model, mice are immunized with house dust mite and then challenged intratracheally with house dust mite to induce airway hyperreactivity, mucus accumulation, eosinophilia and IgE production.
