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Kelly, K. J. et al. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury.
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.
Most importantly, vaccinated mice are protected against morbidity and mortality following challenge with high doses of different influenza virus strains.
Faggioni, R. et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor-α and IL-18.
Furthermore, ERRα inhibition may also facilitate the fight against obesity because ERRα-null mice are protected against high-fat diet-induced obesity43.
These data indicate that Nlrp3 KO mice are protected against inflammation-induced atrophy.
However, LRRK2-deficient mice are protected from experimental autoimmune uveitis (EAU) (Wandu et al., 2015).
Fig. 4 Nlrp3 KO mice are protected from inflammation-induced muscle atrophy.
JNK1-deficient mice are protected against TGF-β1- and bleomycin-induced pro-fibrotic gene expression and pulmonary fibrosis [26].
KRAP−/− mice are protected against diet-induced obesity and insulin resistance under HFD.
Next, we asked whether these mice are protected against increased adiposity induced by a high-fat diet (HFD).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com